Hepatoprotective Efficacy and Chemical Evaluation of Chickpea

Abstract

Liver function tests (LFTs) serve as crucial in clinical practice for detecting liver illness, tracking disease development, and to assess the effects of potentially hepatotoxic medicines. Common LFTs include serum aminotransferases, alkaline phosphatase, bilirubin, albumin, & prothrombin time. Elevations of aminotransferases greater than eight times the upper limit are typically indicative of acute viral hepatitis, ischemic hepatitis, or drug- or toxin-induced liver damage. Chronic moderate increases in aminotransferases are more commonly seen than acute hepatitis. Chickpea extract has notable hepatoprotective efficacy against CCl4-induced liver damage in rats. The extract was antioxidative and anti-inflammatory, with lowered glutathione and malondialdehyde levels. It also considerably lowers liver tumour necrosis factor α levels. The histopathological evaluation of liver tissues revealed normal hepatic architecture in extract-treated mice. The extract's safety profile was shown to be excellent, with little acute toxicity. The hepatoprotective effect was linked to the antioxidant & anti-inflammatory characteristics of the isoflavones and phenolic acids.