Ultrasonic Bone Density Measurement: A Biomedical Engineering Victory By A Medical Intervention

Abstract

The broadband ultrasonic attenuation (BUA) and speed of sound (SOS) are commonly used to assess bone density. However, because earlier research has shown that the BUA is sensitive to movement and soft tissue, measurement repeatability will be challenging to obtain. Secondary osteoporosis is a significant co-morbidity associated with inflammatory rheumatic disorders that is caused by a variety of variables such as inflammatory cytokines, inactivity, and glucocorticoid medication. Because of its capacity to identify bone density as well as bone quality, quantitative ultrasonography (QUS) has been used in osteoporosis research. The purpose of this research is to look at the therapeutic potential of deep-sea water (DSW) for osteoporosis. We previously created ovariectomized senescence-accelerated mice (OVX-SAMP8) and demonstrated substantial osteoporosis healing using stem cells and platelet-rich plasma (PRP). The MTT assay revealed a considerable increase in osteoblastic cell (MC3T3) proliferation in deep sea water with a hardness (HD) of 1000. After a 4-month deep sea water therapy, bone mineral density (BMD) was dramatically raised, followed by significantly increased trabecular numbers by micro-CT examination, and biochemistry investigation revealed that blood alkaline phosphatase (ALP) activity was lowered. Bone marrow-derived stromal cells (BMSCs) were collected and studied for stage-specific osteogenesis. Workforce aging is becoming a major public health issue as a result of the growth of age-related disorders such as osteoporosis. Osteoporosis prevention and early identification are critical for avoiding bone fractures and their associated socioeconomic impact. Parkinson's disease (PD) is a prevalent neurological condition among the elderly, with a significant risk of falling. There is a lot of research on the link between Parkinson's disease and osteoporosis. The goal of this study is to use calcaneal ultrasound to describe the bone quality of a population with Parkinson's disease and compare it to a healthy control, while accounting for possible gender differences.