Preeclampsia Incidences and Adverse Drug Reactions in Relation to Aspirin Administration: A Comparative Study of Doses 80 mg and 125 mg/day in Indonesian Population

Abstract

This study examined the occurrence of preeclampsia (PE) and the side effects of low-dose Aspirin therapy (80mg versus 125mg) in high-risk pregnant women. Participants were randomly assigned to receive either 80mg or 125mg of Aspirin until 36 weeks of gestation, and outcomes were assessed post-delivery. Of the 93 women involved, 47 received 80mg and 46 received 125mg of Aspirin. While three women in the 80mg group developed PE compared to one in the 125mg group, the difference was not statistically significant (p>0.05). Maternal outcomes and Aspirin side effects were also similar between the groups (p>0.05). Fetal outcomes showed no significant difference in Apgar scores (p=0.054), but a better systolic decrease was associated with the 125mg dose (p=0.015). In conclusion, administration of either 80mg and 125mg Aspirin doses from 12-16 weeks gestation demonstrated comparable effectiveness in preventing PE, with similar maternal outcomes, PE incidence, and drug side effects in Indonesian population.