Investigate the Correlation Between Antibiotics Resistance of Bacteria and Quaternary Ammonium Compounds (QACs) Resistance in Maternity Wards

Abstract

Nosocomial infections (NIs) provide a considerable challenge in healthcare facilities, as their management challenges contribute to extended hospitalization periods, increased costs, and elevated mortality rates among patients. In order to mitigate the spread of this illness, disinfectants that possess a wide range of antibacterial properties, such as quaternary ammonium compounds (QACs), are employed. This study was conducted to assess the effectiveness of QACs as a disinfectant using a variety of dilution agents. It also investigates the potential correlation between disinfectant resistance and antibiotic resistance. Samples were collected from various areas within maternity wards, including beds, floors, and chairs. These samples were then subjected to diagnosis using the biomerieux vitek®2 system and treated with varying amounts of QACs. A total of 54 samples were tested, distributed as follows: 22 samples representing floors, 24 samples representing beds, and eight samples representing chairs. The analysis revealed the presence of multidrug-resistant bacteria (MDR) in the bacterial samples, indicating resistance to several types of antibiotics. Additionally, a portion of the bacteria isolated from maternity wards exhibited resistance to disinfectants. As with antibiotic resistance, some kinds of bacteria have been found to be resistant to disinfectants. This is because they have developed resistance genes, which have to do with how they are used and how long they are exposed to disinfectants. A potential correlation between bacterial resistance to antibiotics and disinfectants exists, thereby emphasizing the need for proper usage of antiseptics, including appropriate dilution, adherence to disinfectant contact duration, and application to suitable surfaces.