Administration of Beta glucan on humeral immunity after Foot and mouth disease vaccine in Local Awassi Male Lambs

Abstract

This study aimed to investigate the stimulating impact of orally given β-glucan extracted from brewing  yeast Saccharomyces cerevisiae on leukocyte functions and immunization responses in lambs. Ten healthy male awassi lambs (weighting an average of 18.2 kg) were divided into two groups (A and B), each with five animals, and given the foot-and-mouth vaccination. Lambs from group A received 4 mg/kg of beta glucan (β-glucan) orally once daily for 60 days after vaccinated with (ARRIAH-VAC) intramuscularly in the neck at a dose of 1 ml while another group B consider as control group that  vaccinated with (ARRIAH-VAC) intramuscularly in the neck at a dose of 1 m . Blood was drawn from the jugular vein at the start of the trial (day 0), as well as on days 15, 30, and 60 of the experiment to evaluate the chosen markers of humoral immunity in lambs. After immunization, ELISA was used to assess antibody titers against FMD vaccine types A,O and Asia with significant (P>0.05) at days 15 and 30. Our findings show that oral administration of beta glucan following FMD vaccinations can overcome antibodies to induce significant and strong antibody responses in growing lambs.