Histological and Morphometric Parameters Study of Human Neonatal Liver in Kirkuk City

Abstract

Background: The liver is the largest organ in a newborn's body, and it is situated in the upper abdominal cavity, and is responsible for around (2) to (3) percent of an average person's total weight. Liver has some important roles in the body by performs several essential functions such as detoxification, protein synthesis, bile production, and nutrient storage, works synchronously with numerous other organs,, to maintenance the homeostatic mechanisms.

Aim: The current study aims studying the histological and morphometric parameters of the human neonatal livers in the Kirkuk city. Many investigators have been worked on the adult liver in human, but there are few previous studies about the neonate liver, Thus the main aim of the present study is to clarify and compare the findings about neonatal liver with that of the other researchers.

Patients and methods: An autopsy of 30 cadavers within forensic medicines unites at Kirkuk governorates had been achieved, with age ranging from 1-29 days ,50-55 cm length, and 2.7- 6 kg body weight were examined, during the period from Nov 2022 to Jun 2023. The cadavers were inspected grossly for studying the anatomical features and the tissue from each sample were fixed and examined by using leica microscope for studying the histological feature and measuring some features diameters and size.

Results:  The current study showed, that the liver of the neonate is surrounded from outside by a layer of dens irregular connective tissue which represents the capsule.  The microscopic examination of the capsule showed that it consists of a non-thick layer of irregularly arranged collagen fibers, the parenchyma of the liver consists of the hepatocytes, hepatocytes was arranged in palate, the classical lobule in the neonate liver was hexagonal in shape.

In conclusion, this study provides evidence of the histological feature, and other morphometric parameters of human neonatal liver. morphometric parameters of human neonatal liver by using leica microscope, applicable and reproducible estimates in calculating normal liver histological parameters. I think that my study may be a reference for similar studies to be done in the upcoming years.