Evaluate The Level And Correlation Of Proinflammatory Marker Visfatin And Tumor Necrosis Factor Alpha (TNF-Α) In Obese And Non-Obese PCOS Women

Abstract

PCO is an endocrinopathy disorder that is characterized by hyperandrogenism irregular period, hair growth and acne on face, irregular or complete absence of ovulation resulting   difficulty in conceiving. PCO is more commonly encountered endocrine disorder among 20 % females of reproductive age in Pakistan. PSO is responsible for different morbidity in women.

Aim of study: To evaluate the level of visfatin and TNF-α and correlate obesity with visfatin and TNF-α in obese and non-obese PCOS women with their respective healthy individual In best of our knowledge we are first how are reported correlation among visfatin and TNF-α and correlate these hormones in both lean and obese PCOS women.

Methods: A comparative cross-sectional study was conducted on obese and non-obese PCO women with their respective healthy induvial .30 in each group. biochemical estimation was done on Eliza machine.

Statistical analysis: Statistical analysis was performed by using SPSS 25. One way ANOVA test was used to compare the average of numeric data and chi-square was used to compare categorial data. Pearson correlation test was used to determine the [1]correlation among PCO, visfatin, TNF-α and obesity .value is ≤ 0.05 consider significant.

Results: We found a significant increase in serum visfatin and TNF-α in obese and non-obese PCOS women. We found positive correlation of among PCOS, visfatin, TNF-α and obesity.

Conclusion: We found the significant increase in both biochemical parameter visfatin and TNF-α in both obese and non-obese PCO women with their respective control. but when we compare obese and non-obsess PCO women, Obese PCO women have high level of these biochemical parameter. Its mean both group of PCO have intensity to produce PCO but obese people have high risk to develop PCO.By changing sedentary lief style and food consumption can be help full to cure the symptoms.