Overview Of X-Ray Crystallography In Drug Discovery And Development: A Review

Abstract

X-ray crystallography is crucial in drug discovery and development by giving detailed structural data about target proteins and their interactions with[1] potential drug candidates. This review aims to provide an overview of the application of X-ray crystallography in the pharmaceutical industry, focusing on its role in understanding protein-ligand interactions, guiding rational drug design, and aiding in structure-based drug optimization. The study utilized secondary data from a variety of sources, including published research articles, review papers, and databases, to comprehensively review the current state of X-ray crystallography in drug discovery. Key topics covered include the basic principles of X-ray crystallography, the process of protein crystallization, data collection, and structure determination, as well as the challenges and limitations associated with this technique. By highlighting the successes and limitations of X-ray crystallography in drug discovery, this review aims to provide insights that can help researchers optimize the use of this powerful tool in the development of novel therapeutics. Ultimately, a better understanding of the role of X-ray crystallography in drug discovery and development can lead to the design of more effective and specific drug molecules with improved safety profiles.